What is semaglutide, and how is it different from other weight-loss medications?

Semaglutide is the active ingredient in a class of medications called GLP-1 receptor agonists. It works by mimicking a natural gut hormone (GLP-1) that helps regulate appetite, slows how quickly food leaves your stomach, and affects blood sugar control. In Canada, the same active ingredient is sold under different brand names depending on what it's approved for: Ozempic is approved for type 2 diabetes management, while Wegovy is approved specifically for chronic weight management. Same molecule, different approved use, dose, and branding. It's different from tirzepatide (sold as Mounjaro for diabetes and Zepbound for weight loss), which acts on two hormone receptors (GLP-1 and GIP) instead of one, and it works differently from older-generation appetite suppressants that act through stimulant-like pathways rather than gut hormone signaling. References: https://obesitycanada.ca/healthcare-professionals/adult-clinical-practice-guideline/