What does it actually feel like in the first few weeks on semaglutide?

It varies a lot person to person, but common early experiences include some nausea (especially around dose increases), reduced appetite that builds gradually rather than hitting all at once, and for some people, mild fatigue or digestive changes as the body adjusts. Most people find the more intense GI symptoms settle down within the first several weeks at a given dose, before the next increase restarts the adjustment period a bit. References: https://obesitycanada.ca/healthcare-professionals/adult-clinical-practice-guideline/

First two weeks were rough with nausea for me, then it mellowed out a lot. Every dose bump brought a bit of it back but each time it was milder than the last.