What does it actually feel like in the first few weeks on tirzepatide?

Similar general pattern to other GLP-1 medications. Nausea and appetite suppression are the most commonly reported early effects, often more noticeable around dose increases than at a stable dose. Some people report tirzepatide's appetite suppression feels stronger than what they experienced on semaglutide, though that's individual and not universal. References: https://obesitycanada.ca/healthcare-professionals/adult-clinical-practice-guideline/

Genuinely felt the appetite drop faster on this than I expected, week one I was already forgetting to eat lunch. Nausea was there but manageable for me.