Is it common to feel emotional or "off" during the first few weeks of starting a GLP-1 medication?

It's a reasonably commonly reported experience, sometimes attributed to the physical adjustment (nausea, fatigue, appetite changes) affecting overall mood and sense of normalcy, rather than a direct mood effect from the drug itself in every case. If low mood feels significant or persistent rather than a passing adjustment, that's worth flagging to a provider rather than assuming it's just expected side effects. References: https://obesitycanada.ca/healthcare-professionals/adult-clinical-practice-guideline/

First couple weeks I felt weirdly emotional, not sure if it was the adjustment itself or just the novelty of everything changing. Settled down after about a month for me.