What's a realistic timeline before clothes start fitting differently?

This varies a lot by individual, starting weight, and dose, but many people report noticing clothing fit changes somewhere in the 6-12 week range as cumulative weight loss builds, often before hitting a specific number-based milestone on the scale. It's typically gradual rather than a sudden shift, tracking with the overall gradual dose titration and weight loss pattern. References: https://obesitycanada.ca/healthcare-professionals/adult-clinical-practice-guideline/