Does GLP-1 medication affect mood, one way or the other?

Reports vary. Some people describe feeling better mood-wise as weight and blood sugar stabilize and physical symptoms improve, while others report low mood or emotional flatness, particularly during periods of nausea or reduced eating. Mood-related effects have been part of ongoing safety monitoring discussions for this medication class generally, which is part of why providers typically ask about mood changes at follow-ups rather than assuming it's a non-issue either direction. References: https://obesitycanada.ca/healthcare-professionals/adult-clinical-practice-guideline/