Does Wellbutrin work for ADHD on its own, or only as an add-on to a stimulant?

Wellbutrin, bupropion, is not labelled for ADHD in Canada, whether it is used on its own or added to a stimulant. Health Canada indications are for depression and other labelled uses depending on the product, not ADHD. CADDRA guidelines place bupropion among third-line off-label options, alongside medicines such as clonidine and modafinil, and say to consult an ADHD specialist because the use is off-label. If the change is persistent, distressing, or affecting daily functioning, bring a brief timeline to the prescribing clinician rather than changing the dose independently. Related reading: https://www.fastreat.com/en/blogs/adhd-medication References: https://www.caddra.ca/wp-content/uploads/Canadian-ADHD-Practice-Guidelines-4.1-January-6-2021.pdf https://pmc.ncbi.nlm.nih.gov/articles/PMC6109107/ https://www.camh.ca/en/professionals/treating-conditions-and-disorders/adult-adhd/adult-adhd---treatment/adult-adhd---pharmacotherapy