Why do some people regain weight quickly after stopping a GLP-1 medication while others don't?

It varies based on factors like how much lifestyle change (exercise habits, eating patterns) was built during treatment, how quickly the body's hunger signals return to baseline after stopping, and individual metabolic factors. People who used the medication period to establish lasting habits sometimes maintain more of their loss, though clinical trial data has generally shown weight regain is common for most people within roughly a year of stopping, even with some lifestyle changes in place, which is part of why many clinicians view it as a long-term therapy rather than a bridge to a medication-free state. References: https://obesitycanada.ca/healthcare-professionals/adult-clinical-practice-guideline/