Does perimenopause change how well GLP-1 medication works for weight loss?

Perimenopause brings hormonal shifts that are independently associated with changes in fat distribution and can make weight management generally more challenging during this window, which may affect how results feel or progress compared to someone outside this life stage, though this reflects the broader metabolic context of perimenopause rather than the drug itself working differently. Setting expectations with a provider familiar with this life stage can help. References: https://obesitycanada.ca/healthcare-professionals/adult-clinical-practice-guideline/